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Roll-to-roll printing has significantly shortened the time from design to production of sensors and IoT devices, while being cost-effective for mass production. But due to less manufacturing tolerance controls available, properties such as sensor thickness, composition, roughness, etc., cannot be precisely controlled. Since these properties likely affect the sensor behavior, roll-to-roll printed sensors require validation testing before they can be deployed in the field. In this work, we improve the testing of Nitrate sensors that need to be calibrated in a solution of known Nitrate concentration for around 1–2 days. To accelerate this process, we observe the initial behavior of the sensors for a few hours, and use a physics-informed machine learning method to predict their measurements 24 hours in the future, thus saving valuable time and testing resources. Due to the variability in roll-to-roll printing, this prediction task requires models that are robust to changes in properties of the new test sensors. We show that existing methods fail at this task and describe a physics-informed machine learning method that improves the prediction robustness to different testing conditions (≈ 1.7× lower in real-world data and ≈ 5× lower in synthetic data when compared with the current state-of-the-art physics-informed machine learning method).